Expectations of Benefit in a Trial of a Candidate Disease-Modifying Treatment for Parkinson Disease.

Tiago A Mestre Eric A MacklinAlberto AscherioJoaquim José FerreiraAnthony E LangMichael A Schwarzschildnull null

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

Participants of a disease-modification trial in PD had likely unrealistic expectations of benefit (ie, improvement in symptoms over years), which may affect clinical trial interpretation and calls for improved education in future disease-modification trials in PD. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

parkinson disease
clinical trial
phase ii
phase iii
study protocol
deep brain stimulation
open label
randomized controlled trial
physical activity
depressive symptoms
sleep quality