Imaging of HER2-Positive Tumors in NOD/SCID Mice with Pertuzumab Fab-Hexahistidine Peptide Immunoconjugates Labeled with [99mTc]-(I)-Tricarbonyl Complex.
Valerie J FaccaNoor Al-SadenAnthony KuRaymond M ReillyPublished in: Molecular imaging and biology (2021)
MicroSPECT/CT with [99mTc]His6-pertuzumab Fab imaged tumors in NOD/SCID mice that exhibited intermediate or high HER2 expression, but not tumors with low HER2. [99mTc]His6-pertuzumab Fab is promising for SPECT imaging of tumor HER2 expression.
Keyphrases
- positron emission tomography
- computed tomography
- poor prognosis
- epidermal growth factor receptor
- high resolution
- metastatic breast cancer
- high fat diet induced
- binding protein
- magnetic resonance imaging
- dual energy
- image quality
- long non coding rna
- innate immune
- contrast enhanced
- fluorescence imaging
- metabolic syndrome