PD-1 does not mark tumor-infiltrating CD8+ T cell dysfunction in human gastric cancer.

Yang ShenYongsheng TengYipin LvYongliang ZhaoYuan QiuWeisan ChenLina WangYing WangFangyuan MaoPing ChengDaiyuan MaYuan ZhuangQuanming ZouLiu-Sheng Peng

Published in: Journal for immunotherapy of cancer (2021)

Our data highlight that GC-derived TGF-β1 promotes PD-1 independent CD8+ T cell dysfunction. Therefore, restoring CD8+ T cell function by a combinational PD-1 and TGF-β1 blockade might benefit future GC immunotherapy.

Keyphrases

transforming growth factor
endothelial cells
oxidative stress
electronic health record
gas chromatography
big data
pluripotent stem cells
simultaneous determination