Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief.
Hye-Yeong LeeGiYoong TaeSaeYeon HwangSungWon WeeYoon HaHye-Lan LeeDongAh ShinPublished in: Biomedicines (2023)
This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain.
Keyphrases
- neuropathic pain
- wound healing
- spinal cord
- spinal cord injury
- endothelial cells
- venous thromboembolism
- drug delivery
- end stage renal disease
- growth factor
- induced pluripotent stem cells
- hyaluronic acid
- chronic kidney disease
- ejection fraction
- newly diagnosed
- stem cells
- tissue engineering
- pluripotent stem cells
- peripheral nerve
- oxidative stress
- chronic pain
- patient reported
- brain injury