Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells.
Leila YousefiHamid Owaysee OsqueeReza GhotaslouMohammad Ahangarzadeh RezaeeTahereh PirzadehJavid SadeghiFatemeh HemmatiBahman YousefiSeyyed Yaghoub MoaddabMehdi YousefiMasoud ShirmohammadiMohammad Hossein SomiKhudaverdi GanbarovHossein Samadi KafilPublished in: BioMed research international (2021)
Helicobacter pylori (H. pylori) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein-coding genes, which may be important in cancer development. Their mechanisms have not been well understood, so we are going to investigate the risk of GC in a population with both high lncRNA and H. pylori infection.
Keyphrases
- helicobacter pylori
- helicobacter pylori infection
- gas chromatography
- long non coding rna
- poor prognosis
- genome wide
- pseudomonas aeruginosa
- genome wide identification
- escherichia coli
- staphylococcus aureus
- genome wide analysis
- long noncoding rna
- papillary thyroid
- binding protein
- gene expression
- network analysis
- biofilm formation
- copy number
- young adults
- antimicrobial resistance
- squamous cell
- cystic fibrosis
- tandem mass spectrometry
- small molecule