RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity.
Laerke PriskornSandra Søgaard TøttenborgKristian AlmstrupAnna-Maria AnderssonJonatan AxelssonElvira Vaclavik BräunerAngel ElenkovNina la Cour FreieslebenYvonne Lundberg GiwercmanMarie Louise GrøndahlAnn Holm HansenLaura Smidt HansenEmir HenicMargareta Laczna KitlinskiSelma Kloeve LandersoeChristian H LindhEllen Christine Leth LøkkegaardJohan MalmKristina Wendelboe OlsenKajsa Ugelvig PetersenLone SchmidtSacha StormlundPernille Fog SvendsenDitte VassardNathalie Friis WangAnne ZedelerShalender BhasinJorge E ChavarroMichael L EisenbergRuss HauserIlpo T HuhtaniemiStephen A KrawetzGyorgy Marko-VargaAlessia d'ArmaJorma ToppariAnders JuulNiels JørgensenHenriette Svarre NielsenAnja PinborgLars RylanderAleksander GiwercmanPublished in: Andrology (2021)
ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.
Keyphrases
- polycystic ovary syndrome
- risk factors
- end stage renal disease
- quality improvement
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- pregnant women
- physical activity
- insulin resistance
- intimate partner violence
- prognostic factors
- type diabetes
- cross sectional
- adipose tissue
- metabolic syndrome
- patient reported outcomes
- patient reported
- combination therapy
- adverse drug
- early life