MRI proton density fat fraction for estimation of tumor grade in steatotic hepatocellular carcinoma.

Patrick Arthur KupczykDarius KurtChristoph EndlerJulian Alexander LuetkensGuido Matthias KukukFlorian FronhoffsHans-Peter FischerUlrike Irmgard AttenbergerClaus Christian Pieper

Published in: European radiology (2023)

• MRI proton density fat fraction mapping enables distinction between well- (G1) and less- (G2 and G3) differentiated steatotic hepatocellular carcinomas. • In a retrospective single-center study with 62 histologically proven steatotic hepatocellular carcinomas, G1 tumors showed a higher intralesional fat content than G2 and G3 tumors (7.9% vs. 4.4% and 4.7%; p = .004). • In liver steatosis, MRI proton density fat fraction mapping was an even better discriminator between G1 and G2/G3 steatotic hepatocellular carcinomas.

Keyphrases

adipose tissue
contrast enhanced
magnetic resonance imaging
high grade
fatty acid
diffusion weighted imaging
high fat diet
computed tomography
magnetic resonance
mass spectrometry