Identification and characterization of murine glycoprotein 2-expressing intestinal dendritic cells.
Katarzyna M LudaClement Da SilvaFatemeh AhmadiAllan Mcl MowatHiroshi OhnoKnut KotarskyWilliam W AgacePublished in: Scandinavian journal of immunology (2022)
The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103 + CD11b + cDC in the murine small intestine (SI). GP2 expression was induced on CD103 + CD11b + cDC within the SI-LP and was regulated by IRF4, TGFβR1- and retinoic acid signalling. Mice selectively lacking Gp2 on CD103 + CD11b + cDC (huLang-Cre.gp2 fl/fl mice) had normal numbers and proportions of innate and adaptive immune cells in the SI-LP suggesting that GP2 expression by CD103 + CD11b + cDC is not required for intestinal immune homoeostasis.
Keyphrases
- dendritic cells
- immune response
- cell cycle
- poor prognosis
- binding protein
- regulatory t cells
- room temperature
- high fat diet induced
- cell proliferation
- type diabetes
- high glucose
- protein protein
- skeletal muscle
- signaling pathway
- wild type
- epithelial mesenchymal transition
- small molecule
- diabetic rats
- drug induced
- ionic liquid