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Chelerythrine ameliorates Aspergillus fumigatus keratitis through suppressing the LOX-1/p38 MAPK signaling pathway.

Wenyao LiuYinghe QiWeilin DiaoJing LinLina ZhangQian WangLingwen GuZhuhui FengMenghui ChiYuwei WangWendan YiYuqi LiCui LiGuiqiu Zhao
Published in: Cytokine (2024)
CHE provides protection against A. fumigatus keratitis through multiple mechanisms, including reducing fungal survival, inducing anti-inflammatory effects, enhancing Nrf2 and HO-1 expression, and suppressing the signaling pathway of LOX-1/p38 MAPK.
Keyphrases
  • signaling pathway
  • pi k akt
  • induced apoptosis
  • epithelial mesenchymal transition
  • poor prognosis
  • oxidative stress
  • mouse model
  • low density lipoprotein
  • binding protein
  • cell proliferation
  • long non coding rna