Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells.

Jing LiangQi LiWenbin CaiXuejiao ZhangBing YangXin LiShuai JiangShanshan TianKai ZhangHao SongDing AiXu ZhangChunjiong WangYi Zhu

Published in: British journal of pharmacology (2019)

Vascular injury elevated the expression of EZH2 and the downstream target H3K27me3, which suppressed p16INK4A expression in VSMCs and promoted VSMC proliferation and neointimal hyperplasia. EZH2 inhibition might be a potential therapeutic target for restenosis.

Keyphrases

vascular smooth muscle cells
angiotensin ii
poor prognosis
long non coding rna
binding protein
signaling pathway
long noncoding rna
smooth muscle