High-Flow Nasal Cannula Therapy for Exertional Dyspnea in Patients with Cancer: A Pilot Randomized Clinical Trial.
David HuiDonald A MahlerLiliana LarssonJimin WuSaji ThomasCarol A HarrisonKenneth HessJuan Lopez-MatteiKara ThompsonDaniel GomezMelenda JeterSteven LinKaren Basen-EngquistEduardo BrueraPublished in: The oncologist (2020)
In this four-arm, double-blind, randomized clinical trial examining the role of high-flow nasal cannula on exertional dyspnea in patients with cancer without hypoxemia, high-flow oxygen, but not high-flow air, resulted in significantly lower dyspnea scores and longer exercise time. High-flow oxygen delivered by high-flow nasal cannula devices may improve clinically relevant outcomes even in patients without hypoxemia.
Keyphrases
- double blind
- extracorporeal membrane oxygenation
- end stage renal disease
- respiratory failure
- chronic rhinosinusitis
- positive airway pressure
- newly diagnosed
- chronic kidney disease
- ejection fraction
- clinical trial
- heat stress
- prognostic factors
- obstructive sleep apnea
- placebo controlled
- peritoneal dialysis
- physical activity
- high intensity
- randomized controlled trial
- patient reported outcomes
- metabolic syndrome
- skeletal muscle
- body composition
- phase iii
- resistance training