Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation.

Ning LiQianyin ZhouZhang YiHuan ZhangDai Zhou

Published in: Biological research (2023)

ASB9 is predominantly expressed in human SSCs, it affects the proliferation and apoptotic process of the SSC line through HIF1AN, and its abnormal expression may be associated with NOA.

Keyphrases

endothelial cells
signaling pathway
cell death
induced pluripotent stem cells
oxidative stress
poor prognosis
binding protein
small molecule
cell proliferation