Long non-coding RNAs in virus-related cancers.

Yushan HuangLongchang JiangYang LiuLixian LiuJunling WangLei Shi

Published in: Reviews in medical virology (2022)

Some viral infections lead to tumourigenesis explained by a variety of underlying molecular mechanisms. Long non-coding RNAs (lncRNAs) have the potential to be added to this list due to their diverse mechanisms in biological functions and disease processes via gene alternation, transcriptional regulation, protein modification, microRNA sponging and interaction with RNA/DNA/proteins. In this review, we summarise the dysregulation and mechanism of lncRNAs in virus-related cancers focussing on Hepatitis B virus, Epstein-Barr virus, Human Papillomavirus. We will also discuss the potential implications of lncRNAs in COVID-19.

Keyphrases

long non coding rna
hepatitis b virus
epstein barr virus
poor prognosis
genome wide identification
sars cov
diffuse large b cell lymphoma
genome wide analysis
network analysis
coronavirus disease
liver failure
copy number
transcription factor
gene expression
single molecule
protein protein