Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

Vahinipriya ManoharanEric Hamilton KarunanayakeKamani Hemamala TennekoonSumadee De SilvaAhamed Ilyas Ahamed ImthikabKanishka De SilvaPreethika AngunawelaSameera VishwakulaJohn Lunec

Published in: BMC cancer (2020)

The prevalence of pathogenic somatic TP53 variants was 31 and 33.33% in the studied BC and CRC cohorts respectively. All of them were located in exons 5-8 and the pathogenic missense variants were associated with strong immuno-positive staining for p53.

Keyphrases

copy number
poor prognosis
genome wide
intellectual disability
dna methylation
binding protein
solid state