Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation.
Jianhua CaoMarta Martin-LorenzoKim van KuijkElias B WielandMarion J J GijbelsBritt S R ClaesAngeles HerederoGonzalo AldámizRon M A HeerenPieter G GoossensJudith C SluimerBenjamin BalluffGloria Álvarez-LlamasPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
An altered phospholipid metabolism occurs in atherosclerosis, affecting both the aorta and the adjacent heart tissue. Plaque-progression lipids lysophosphatidylcholine(18:0) and lysophosphatidic acid(18:1), as identified by MS imaging on tissue, reflect cardiovascular risk in human plasma.