A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer.

Francisca Nunes de AlmeidaAlessandro VasciaveoAinsley Mike AntaoMin ZouMatteo Di BernardoSimone de BrotAntonio Rodriguez-CaleroAlexander ChuiAlexander L E WangNicolas Floc'hJaime Y KimStephanie N AfariTimur MukhammadovJuan Martín ArriagaJinqiu LuMichael M ShenMark A RubinAndrea CalifanoCory Abate-Shen

Published in: bioRxiv : the preprint server for biology (2024)

Using an unbiased forward mutagenesis screen in an autochthonous mouse model, we have investigated mechanistic determinants of aggressive prostate cancer. SIRT1 emerged as a key regulator of neuroendocrine prostate cancer differentiation and a potential target for therapeutic intervention.

Keyphrases

prostate cancer
radical prostatectomy
mouse model
high throughput
genome wide
randomized controlled trial
oxidative stress
crispr cas
transcription factor
dna methylation
ischemia reperfusion injury
risk assessment
single cell
high resolution
high speed