Understanding pneumococcal serotype 1 biology through population genomic analysis.
Chrispin ChaguzaJennifer E CornickSimon R HarrisCheryl P AndamLaura Bricio-MorenoMarie YangFeyruz YalcinSani OusmaneShanil GovindpersadMadikay SenghoreChinelo EbrukeMignon Du PlessisAnmol M KiranGerd PluschkeBetuel SigauqueLesley McGeeKeith P KlugmanPaul TurnerJukka CoranderJulian ParkhillJean-Marc CollardMartin AntonioAnne von GottbergRobert S HeydermanNeil FrenchAras KadiogluWilliam P HanageDean B EverettStephen D Bentleynull nullPublished in: BMC infectious diseases (2016)
The high phylogeographic diversity of the ST217 clone shows that this clone has been in circulation globally for a long time, which allowed its diversification and adaptation in different geographical regions. Such geographic adaptation reflects local variations in selection pressures in different locales. Further studies will be required to fully understand the biological mechanisms which makes the ST217 clone highly invasive but unable to successfully colonise the human nasopharynx for long durations which results in lower recombination rates.