Relationship between tumor-associated immune infiltrate and p16 staining over clinicopathological features in acral lentiginous melanoma.
Carlos A CastanedaMiluska CastilloCarlos A Torres-CabalaLuis A BernabeSandro CasavilcaV VillegasJoselyn SanchezMiguel De La CruzJorge Antonio Dunstan YatacoJose M CotrinaHenry L GómezCarlos ChavezMaria P Landa-BaellaKatherine TelloBrayam FelixJulio E AbugattasPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)
Higher levels of TIL tend to be associated with better overall survival in ALM. Loss of expression of p16 is associated with lower levels of CD3+ and CD8+ TIL, indicating a probable relationship between p16 and TIL immune response in ALM .