Allicin Reduces 5-fluorouracil-resistance in Gastric Cancer Cells through Modulating MDR1, DKK1, and WNT5A Expression.

Parya Khakbaz Reza Panahizadeh Mohammad Amin Vatankhah Najafzadeh Nowruz

Published in: Drug research (2021)

Our findings indicate that the combination of allicin with 5-FU could reverse multidrug resistance in the GC cells by reducing the expression of WNT5A, DKK1, MDR1, P-gp, and CD44 levels.

Keyphrases

poor prognosis
multidrug resistant
stem cells
cell proliferation
induced apoptosis
binding protein
signaling pathway
cell cycle arrest
oxidative stress
mass spectrometry
cell death
high resolution
endoplasmic reticulum stress