Salvage irreversible electroporation for radio-recurrent prostate cancer - the prospective FIRE trial.

Alexandar Blazevski Bart GeboersMatthijs J ScheltemaWilliam GondoputroPaul DoanAthos KatelarisShikha AgrawalDaniela BarettoJayne MatthewsAnne-Maree HaynesWarick DelpradoRon ShnierWillemien van den BosJames E Thompson Nathan L Lawrentschuk Phillip D Stricker

Published in: BJU international (2022)

The FIRE trial shows that salvage IRE after failed radiation therapy for localised PCa is safe with minimal toxicity, and promising functional and oncological outcomes. Salvage IRE can offer a possible solution for notoriously difficult to manage radio recurrent prostate tumours.

Keyphrases

prostate cancer
radical prostatectomy
phase iii
study protocol
endoplasmic reticulum stress
phase ii
clinical trial
oxidative stress
rectal cancer
randomized controlled trial
open label
type diabetes
benign prostatic hyperplasia
robot assisted
metabolic syndrome
minimally invasive
skeletal muscle
double blind