IL-33 Expression Is Lower in Current Smokers at Both Transcriptomic and Protein Level.
Alen FaizRashad M MahbubFia Sabrina BoedijonoMilan I TomassenWierd KooistraWim TimensMartijn NawijnPhilip M HansbroMatt D JohansenSimon D PouwelsIrene H HeijinkFlorian MassipMaria Stella de BiaseRoland F SchwarzIssssswan M AdcockKian F ChungAnne van der DoesPieter S HiemstraHelene GoulaouicHeming XingRaolat AbdulaiEmanuele de RinaldisDanen CunoosamySivan HarelDavid LedererMichael C NivensPeter A B WarkHuib A M KerstjensMachteld N HylkemaCorry-Anke BrandsmaMaarten van den Bergenull nullPublished in: American journal of respiratory and critical care medicine (2023)
We provide strong evidence that cigarette smoke leads to an overall reduction in IL33 expression in both transcriptomic and protein level and this may be due to the decrease in resting basal cells. Together, these findings may explain the clinical observation that a recent antibody-based anti-IL-33 treatment is more effective in ex- than current smokers with COPD. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).