Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice.

Pavlina ChuntovaYafei HouRyosuke NakaAkane YamamichiTiffany ChenYitzhar GoretskyRyusuke HataeTakahide NejoGary KohanbashAbigail L MendeMegan MontoyaKira M DowneyDavid DieboldJayne SkinnerHong-Erh LiangBjoern SchwerHideho Okada

Published in: Neuro-oncology (2021)

Our new syngeneic CAR Tg mouse model can serve as a useful tool to address clinically relevant questions and develop future immunotherapeutic strategies.

Keyphrases

mouse model
current status
high fat diet induced
case control
wild type
mesenchymal stem cells