A Western-Type Dietary Pattern Induces an Atherogenic Gene Expression Profile in the Coronary Arteries of the Ossabaw Pig.
Maura E WalkerNirupa R MatthanStefania Lamon-FavaGloria Solano-AguilarSaebyeol JangSukla LakshmanAleksey MolokinJoseph F UrbanTyler FaitsWilliam Evan JohnsonAlice H LichtensteinPublished in: Current developments in nutrition (2019)
These data suggest that a WD induces alterations in the transcriptome of the coronary artery consistent with an inflammatory atherogenic phenotype in the Ossabaw pig with no significant modification by concurrent statin therapy.
Keyphrases
- coronary artery
- pulmonary artery
- low density lipoprotein
- coronary artery disease
- genome wide
- gene expression
- south africa
- cardiovascular disease
- electronic health record
- oxidative stress
- rna seq
- single cell
- copy number
- type diabetes
- heart failure
- stem cells
- mesenchymal stem cells
- aortic valve
- pulmonary hypertension
- replacement therapy
- genome wide identification
- smoking cessation
- ejection fraction