Targeted Assessment of Mucosal Immune Gene Expression Predicts Clinical Outcomes in Children with Ulcerative Colitis.

Kathryn ClarkstonRebekah KarnsAnil G JeggaMihika SharmaSejal FoxBabajide A OjoPhillip MinarThomas D WaltersAnne M GriffithsDavid R MackBrendan BoyleNeal S LeLeikoJames MarkowitzJoel R RoshAshish S PatelSapana ShahRobert N BaldassanoMarian PfefferkornCary SauerSubra KugathasanYael HabermanJeffrey S HyamsLee A Denson Michael J Rosen

Published in: Journal of Crohn's & colitis (2022)

Targeted assessment of rectal mucosal immune gene expression predicts 52-week CSFR in treatment-naïve paediatric UC patients. Further exploration of IL-13Rɑ2 as a therapeutic target in UC and future studies of the epithelial-specific role of RORC in UC pathogenesis are warranted.

Keyphrases

gene expression
ulcerative colitis
end stage renal disease
dna methylation
ejection fraction
chronic kidney disease
newly diagnosed
cancer therapy
emergency department
intensive care unit
peritoneal dialysis
patient reported outcomes
clinical evaluation