Maresin 1 intervention reverses experimental pulmonary arterial hypertension in mice.

Hui LiXinyu LiYu HaoChenghua WuYuhao FuNana SuHoulin ChenBinyu YingHaixing WangLihuang SuHaijian CaiQinlian HeMengsi CaiJunwei SunJing LinAaron ScottFanggao SmithXiaoying HuangShengwei Jin

Published in: British journal of pharmacology (2022)

Maresin 1 improved abnormal pulmonary vascular remodelling and right ventricular dysfunction in PAH mice, targeting aberrant PASMC proliferation. This suggests Maresin 1 may have a potent therapeutic effect in vascular disease.

Keyphrases

pulmonary arterial hypertension
pulmonary hypertension
pulmonary artery
high fat diet induced
randomized controlled trial
oxidative stress
signaling pathway
type diabetes
cancer therapy
adipose tissue
drug delivery