Predictive model identifies strategies to enhance TSP1-mediated apoptosis signaling.

Published in: Cell communication and signaling : CCS (2017)

This new mathematical model recapitulates the intracellular dynamics of the TSP1-induced apoptosis signaling pathway. Overall, the modeling framework predicts molecular strategies that increase TSP1-mediated apoptosis, which is useful in many disease settings.

Keyphrases

induced apoptosis
signaling pathway
endoplasmic reticulum stress
oxidative stress
pi k akt
epithelial mesenchymal transition
genome wide
reactive oxygen species
gene expression
single molecule