Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis.
Siavash FazelianFatemeh MoradiShahram AgahAkramsadat HoseiniHafez HeydariMojgan MorvaridzadehAmirhosein OmidiAna Beatriz PizarroAtie GhafouriJavad HeshmatiPublished in: BMC nephrology (2021)
Finally, thirteen articles met the inclusion criteria for this review omega-3 FAs supplementation significantly decrease TC (SMD: -0.26; 95% CI: - 0.51, - 0.02; I2 = 52.7%), TG (SMD: -0.22; 95% CI: - 0.43, - 0.02; I2 = 36.0%) and Malondialdehyde (MDA) levels (SMD: -0.91; 95% CI: - 1.29, - 0.54; I2 = 00.0%) and also significantly increase superoxide dismutase (SOD) (SMD: 0.58; 95% CI: 0.27, 0.90; I2 = 00.0%) and Glutathione peroxidase (GPx) (SMD: 0.50; 95% CI: 0.14, 0.86; I2 = 00.0%) activities. However our results show that omega-3 FAs supplementation have no significant effects on HDL, LDL and blood pressure. Conclusion This systematic review and meta-analysis supports current evidence for the clinical benefit of omega-3 FAs intake to improve cardiometabolic parameters in CKD patients. However, well-designed RCTs still needed to provide a conclusive picture in this field.
Keyphrases
- end stage renal disease
- chronic kidney disease
- blood pressure
- oxidative stress
- fatty acid
- ejection fraction
- newly diagnosed
- hydrogen peroxide
- peritoneal dialysis
- prognostic factors
- type diabetes
- heart rate
- metabolic syndrome
- hypertensive patients
- blood glucose
- insulin resistance
- ischemia reperfusion injury
- signaling pathway
- pi k akt
- cell proliferation
- low density lipoprotein