Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats.

Marcos UchaDavid Roura-MartínezRaquel Santos-ToscanoRoberto CapellánEmilio AmbrosioAlejandro Higuera-Matas

Published in: Psychopharmacology (2022)

These results suggest that heroin self-administration under extended access conditions modifies the expression profile of activators and components of the mTOR complexes and show a putative irresponsive mTOR complex 2 after withdrawal from heroin use.

Keyphrases

cell proliferation
poor prognosis
prefrontal cortex
functional connectivity
genome wide
dna methylation
gene expression
binding protein
resting state
drug induced