GATA6-positive lung adenocarcinomas are associated with invasive mucinous adenocarcinoma morphology, hepatocyte nuclear factor 4α expression, and KRAS mutations.

Naoki NakajimaAkihiko YoshizawaTomoyuki NakajimaMasahiro HirataAyako FuruhataShinji SumiyoshiMariyo Rokutan-KurataMakoto SonobeToshi MenjuEi MiyamotoToyofumi F Chen-YoshikawaHiroshi DateHironori Haga

Published in: Histopathology (2018)

These findings suggest that GATA6 might interact with HNF4α and contribute to the development of mucinous-type LAs.

Keyphrases

nuclear factor
low grade
transcription factor
toll like receptor
poor prognosis
squamous cell carcinoma
high grade
locally advanced
wild type