Pharmacological Notch pathway inhibition leads to cell cycle arrest and stimulates ascl1 and neurogenin2 genes expression in dental pulp stem cells-derived neurospheres.

Ali NiapourHatef Ghasemi HamidabadiNazila NiapourPerham MohammadiMarzieh Sharifi PasandiVadoud Malekzadeh

Published in: Biotechnology letters (2019)

Our findings demonstrated the Notch activity in hDPSCs-neurospheres. DAPT treatment positively regulated proneural genes expression and increased neuronal-like differentiation.

Keyphrases

stem cells
poor prognosis
cell cycle arrest
genome wide
cell death
cell proliferation
binding protein
transcription factor
genome wide identification
bioinformatics analysis
long non coding rna
gene expression
acute coronary syndrome
percutaneous coronary intervention
mesenchymal stem cells
replacement therapy