Mosaicism: Implications for Genetic Counseling and Medical Management.
Laura WaldmanSuzanne M MahonPublished in: Clinical journal of oncology nursing (2018)
Mosaicism describes the presence of two or more populations of cells with different genotypes in one individual that have developed from a single fertilized egg. This article reviews the various clinical presentations of mosaicism associated with hereditary cancer syndromes and the challenges in providing patients and their families with appropriate genetic testing, as well as provides recommendations for cancer presentation and early detection. Management of mosaicism is based on personal and family history, along with genetic testing results.
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Keyphrases
- papillary thyroid
- end stage renal disease
- squamous cell
- ejection fraction
- induced apoptosis
- newly diagnosed
- healthcare
- chronic kidney disease
- prognostic factors
- squamous cell carcinoma
- randomized controlled trial
- oxidative stress
- cell cycle arrest
- smoking cessation
- case report
- patient reported outcomes
- young adults
- systematic review
- gene expression
- cell proliferation
- cell death
- hepatitis c virus
- endoplasmic reticulum stress
- hiv infected
- patient reported