The association between interleukin-6 gene -174G/C single nucleotide polymorphism and sepsis: an updated meta-analysis with trial sequential analysis.

Published in: BMC medical genetics (2019)

IL-6-174 G/C polymorphism is not associated with the risk and mortality of sepsis. Trial sequential analysis showed that a large sample size was needed to get a more reliable result of the association between IL-6-174 G/C polymorphism and sepsis in non-adults.

Keyphrases

systematic review
intensive care unit
acute kidney injury
septic shock
clinical trial
phase ii
type diabetes
gene expression
risk factors
cardiovascular events
randomized controlled trial
copy number
transcription factor