Dysfunctional dendritic cells limit antigen-specific T cell response in glioma.

Mirco FriedrichMarkus HahnJulius MichelRoman SankowskiMichael KilianNiklas KehlManina GünterTheresa BunseStefan PuschAndreas von DeimlingWolfgang WickStella E AutenriethMarco PrinzMichael PlattenLukas Bunse

Published in: Neuro-oncology (2022)

Glioma-associated DCs are relevantly abundant in human IDH wildtype and mutant tumors. Glioma IDH mutations result in specifically educated, dysfunctional DCs via paracrine reprogramming of infiltrating monocytes, providing the basis for combinatorial immunotherapy concepts against IDH mutant gliomas.

Keyphrases

wild type
dendritic cells
low grade
high grade
endothelial cells
immune response
induced pluripotent stem cells
pluripotent stem cells