Access to 4-Trifluoromethyl Quinolines via Cu-Catalyzed Annulation Reaction of Ketone Oxime Acetates with ortho -Trifluoroacetyl Anilines under Redox-Neutral Conditions.
Zhen-Hua WangLi-Wen ShenPing YangYong YouJian-Qiang ZhaoWei-Cheng YuanPublished in: The Journal of organic chemistry (2022)
An efficient Cu-catalyzed annulation reaction of ketone oxime acetates with ortho -trifluoroacetyl anilines has been disclosed. With the developed protocol, a series of 4-trifluoromethyl quinolines were obtained in good to excellent yields (58-99%) under redox-neutral conditions. The protocol also could be extended to ferrocene-based ketone oxime acetates for the construction of ferrocene-substituted fluorine-containing quinolines.