The effect of ribociclib on the expression levels of miR-141 and CDK4/6-USP51 signaling pathway genes in MCF-7 and MDA-MB-231 cells.
Shayeste Sadat BaghermaneshMahmood BaratiArshad HosseiniPublished in: PloS one (2024)
We found that ribociclib can inhibit cell growth in a dose- and time-dependent manner. We examined the mRNA expression of 4 genes. After ribociclib treatment, the mRNA expression of CDK6 and MYH10 decreased (p < 0.01, p < 0.05). The mRNA expression of CDON increased (p<0.05), but no significant changes were observed in ZEB1 mRNA expression. Furthermore, the qRT‒PCR results for miR-141 showed that the expression of miR-141 increased (p<0.01) after 72 h of treatment with ribociclib.
Keyphrases
- long non coding rna
- poor prognosis
- cell proliferation
- signaling pathway
- long noncoding rna
- induced apoptosis
- cell cycle
- epithelial mesenchymal transition
- genome wide
- breast cancer cells
- cell cycle arrest
- pi k akt
- oxidative stress
- binding protein
- combination therapy
- endoplasmic reticulum stress
- transcription factor
- left ventricular
- atrial fibrillation
- bioinformatics analysis