Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial.
Samir JaberJoris PensierEmmanuel FutierCatherine Paugam-BurtzPhilippe SeguinMartine FerrandiereSigismond LasockiJulien PottecherPaër-Sélim AbbackBeatrice RiuFouad BelafiaJean-Michel ConstantinDaniel VerzilliGérald ChanquesAudrey De JongNicolas Molinarinull nullPublished in: Intensive care medicine (2024)
Among patients with obesity and hypoxemic respiratory failure following abdominal surgery, use of NIV compared with standard oxygen therapy reduced the risk of reintubation within 7 days, contrary to patients without obesity. However, no interaction was found according to the presence of obesity or not, suggesting either a lack of power to conclude in the non-obese subgroup despite existing differences, or that the statistical difference found in the overall sample was driven by a large effect in the obese subsets.
Keyphrases
- respiratory failure
- weight loss
- metabolic syndrome
- insulin resistance
- extracorporeal membrane oxygenation
- type diabetes
- mechanical ventilation
- high fat diet induced
- weight gain
- bariatric surgery
- adipose tissue
- end stage renal disease
- ejection fraction
- newly diagnosed
- intensive care unit
- chronic kidney disease
- randomized controlled trial
- peritoneal dialysis
- clinical trial
- body mass index
- cell therapy
- study protocol
- replacement therapy