CDX2 inhibits epithelial-mesenchymal transition in colorectal cancer by modulation of Snail expression and β-catenin stabilisation via transactivation of PTEN expression.

Junhui YuShan LiZhengshui XuJing GuoXiaopeng LiYunhua WuJianbao ZhengXuejun Sun

Published in: British journal of cancer (2020)

Our study first uncovered that CDX2 inhibits EMT and metastasis of CRC by regulation of Snail expression and β-catenin stabilisation via transactivation of PTEN expression.

Keyphrases

epithelial mesenchymal transition
poor prognosis
cell proliferation
transforming growth factor
signaling pathway
long non coding rna
pi k akt