Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion.
Yilong ZhaoJun WuDa LiJing LiuWeiqi ChenZongren HouKailun LiuLingling JiangXiaowei ChenLiu WangBao-Yang HuFangrong ZongYukai WangYi-Long WangPublished in: Cell proliferation (2022)
Intravenous injection of IMRCs protected against CCH-induced white matter injury and cognitive impairment inhibition of microglial activation and regulation of microglia polarization.
Keyphrases
- cognitive impairment
- white matter
- multiple sclerosis
- endothelial cells
- inflammatory response
- induced apoptosis
- high glucose
- neuropathic pain
- cell cycle arrest
- oxidative stress
- diabetic rats
- drug induced
- subarachnoid hemorrhage
- transcription factor
- lipopolysaccharide induced
- high dose
- induced pluripotent stem cells
- lps induced
- ultrasound guided
- pluripotent stem cells
- signaling pathway
- low dose
- spinal cord injury
- cerebral blood flow