Analysis of Anti-RNA Polymerase III Antibody-positive Systemic Sclerosis and Altered GPATCH2L and CTNND2 Expression in Scleroderma Renal Crisis.

Edward P SternSandra G GuerraHarry ChinqueVanessa AcquaahDavid González-SernaMarkella PonticosJavier MartinVoon H OngKorsa KhanSvetlana I NihtyanovaMark HarberAine BurnsMaureen D MayesShervin AssassiCarmen FonsecaChristopher P Denton

Published in: The Journal of rheumatology (2020)

Increased expression of 2 candidate proteins, GPATCH2L and CTNND2, in SRC compared with control kidney suggests a potential role in pathogenesis of SRC. For GPATCH2L, this may reflect genetic susceptibility in ARA-positive patients with SSc based upon 2 independent cohorts.

Keyphrases

systemic sclerosis
interstitial lung disease
poor prognosis
tyrosine kinase
public health
binding protein
genome wide
rheumatoid arthritis
copy number
idiopathic pulmonary fibrosis