Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases.

Rakeeb KureshiAngela ZhuJikui ShenStephany Y TzengLeilani R AstrabPaul R SargunasJordan J GreenPeter A CampochiaroJamie B Spangler

Published in: Cellular and molecular bioengineering (2020)

We engineered a novel anti-VEGF protein as a new weapon against retinal diseases and demonstrated safe and noninvasive ocular delivery in rats. Furthermore, our structure-guided design approach presents a general strategy for discovery of targeted protein drugs for a vast array of applications.

Keyphrases

vascular endothelial growth factor
optical coherence tomography
diabetic retinopathy
endothelial cells
optic nerve
protein protein
small molecule
high throughput
amino acid
binding protein
high resolution
cancer therapy
single molecule
mass spectrometry