Genetic profile and patient-reported outcomes in chronic obstructive pulmonary disease: A systematic review.
Hélder MelroJorge GomesGabriela MouraAlda MarquesPublished in: PloS one (2018)
Although a limited number of PRO's have been related to genetic variations, findings suggest that there is a significant association between specific gene variants and the number/severity of exacerbations, depressive symptoms and HRQOL. Further research is needed to confirm these findings and assess the genetic influence on other dimensions of patients' lives, since it may enhance our understanding and management of COPD.
Keyphrases
- patient reported outcomes
- copy number
- genome wide
- depressive symptoms
- chronic obstructive pulmonary disease
- end stage renal disease
- ejection fraction
- chronic kidney disease
- dna methylation
- peritoneal dialysis
- prognostic factors
- gene expression
- lung function
- social support
- physical activity
- anti inflammatory
- transcription factor
- patient reported
- drug induced
- air pollution