Belantamab mafodotin in combination with novel agents in relapsed/refractory multiple myeloma: DREAMM-5 study design.
Ajay K NookaKatja WeiselNiels Wcj van de DonkDavid RoutledgePaula Rodriguez OteroKevin SongHang QuachNatalie CallanderMonique C MinnemaSuzanne TrudelNicola A JacksonChristoph M AhlersEllie ImShinta ChengL SmithNahi HarethGeraldine Ferron-BradyMaria BrouchRocio Montes de OcaSofia PaulBeata HolkovaIra GuptaBrandon E KremerPaul RichardsonPublished in: Future oncology (London, England) (2021)
Belantamab mafodotin (belamaf) is a BCMA-targeted antibody-drug conjugate recently approved as monotherapy for adults with relapsed/refractory multiple myeloma who have received ≥4 prior therapies. Belamaf binds to BCMA and eliminates myeloma cells by multimodal mechanisms of action. The cytotoxic and potential immunomodulatory properties of belamaf have led to novel combination studies with other anticancer therapies. Here, we describe the rationale and design of DREAMM-5, an ongoing Phase I/II platform study evaluating the safety and efficacy of belamaf combined with novel agents, including GSK3174998 (OX40 agonist), feladilimab (an ICOS; GSK3359609), nirogacestat (a gamma-secretase inhibitor; PF-03084014) and dostarlimab (a PD-1 blocker) versus belamaf monotherapy for patients with relapsed/refractory multiple myeloma. Clinical trial registration: NCT04126200 (ClinicalTrials.gov).
Keyphrases
- multiple myeloma
- clinical trial
- open label
- signaling pathway
- induced apoptosis
- pi k akt
- combination therapy
- cell cycle arrest
- cancer therapy
- high throughput
- randomized controlled trial
- phase ii
- study protocol
- risk assessment
- endoplasmic reticulum stress
- angiotensin converting enzyme
- drug delivery
- human health
- chronic pain
- angiotensin ii