The efficacy of ferroptosis-inducing compounds IKE and RSL3 correlates with the expression of ferroptotic pathway regulators CD71 and SLC7A11 in biliary tract cancer cells.

Dino BekricTobias KiesslichMatthias OckerMartina WinklmayrMarkus RitterHeidemarie DobiasMarlena BeyreisDaniel NeureiterChristian Mayr

Published in: PloS one (2024)

Our results demonstrate that induction of ferroptosis is a promising approach to inhibit BTC cell growth and that the sensitivity of BTC cells towards ferroptosis induction might be dependent on molecular markers such as CD71 and SLC7A11.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
poor prognosis
nk cells
transcription factor
oxidative stress
single molecule
signaling pathway