Motor and Non-motor Outcomes of Deep Brain Stimulation across the Genetic Panorama of Parkinson's Disease: A Multi-Scale Meta-Analysis.

Evridiki AsimakidouGeorgia XiromerisiouChristos Sidiropoulos

Published in: Movement disorders clinical practice (2024)

A personalized approach with a variant-based risk stratification within the emerging field of surgicogenomics is needed. Integration of polygenic risk scores in clinical-decision making should be encouraged.

Keyphrases

deep brain stimulation
parkinson disease
systematic review
decision making
obsessive compulsive disorder
meta analyses
genome wide
copy number
case control
randomized controlled trial
dna methylation
gene expression
metabolic syndrome
insulin resistance