This study was conducted to investigate the effects of Reiki on fatigue and anxiety in hemodialysis patients. This study was designed as a randomized controlled study. The population of the study consisted of hemodialysis patients at the hemodialysis clinic of Siirt State Hospital, Turkey, between January and August 2021. The patients were divided into 2 groups: Reiki and control, with 30 patients in each group. The patients in the Reiki group underwent their respective interventions once a day for 4 consecutive weeks (30-35 minutes). The intervention of Reiki reduced fatigue and anxiety in the hemodialysis patients.