Differences and similarities between SARS-CoV and SARS-CoV-2: spike receptor-binding domain recognition and host cell infection with support of cellular serine proteases.
Giovanni A RossiOliviero SaccoEnrica MancinoLuca CristianiFabio MidullaPublished in: Infection (2020)
Novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) became pandemic by the end of March 2020. In contrast to the 2002-2003 SARS-CoV outbreak, which had a higher pathogenicity and lead to higher mortality rates, SARSCoV-2 infection appears to be much more contagious. Moreover, many SARS-CoV-2 infected patients are reported to develop low-titer neutralizing antibody and usually suffer prolonged illness, suggesting a more effective SARS-CoV-2 immune surveillance evasion than SARS-CoV. This paper summarizes the current state of art about the differences and similarities between the pathogenesis of the two coronaviruses, focusing on receptor binding domain, host cell entry and protease activation. Such differences may provide insight into possible intervention strategies to fight the pandemic.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- single cell
- randomized controlled trial
- cell therapy
- computed tomography
- magnetic resonance imaging
- coronavirus disease
- binding protein
- cardiovascular events
- transcription factor
- staphylococcus aureus
- cardiovascular disease
- risk factors
- mesenchymal stem cells
- antiretroviral therapy
- dengue virus
- dna binding
- aedes aegypti