Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: a translational study.

Marina Cerrone Grecia M Marrón-Liñares Chantal J M van Opbergen Sarah Costa Mimount BourfissMarta Pérez-HernándezFlorencia Schlamp Fabian Sanchis-Gomar Kabir MalkaniKamelia DrenkovaMingliang ZhangXianming LinAdriana HeguyBirgitta K VelthuisNiek H J Prakken Andre La Gerche Hugh Calkins Cynthia A James Anneline S J M Te Riele Mario Delmar

Published in: European heart journal (2022)

We speculate that exercise challenges a cardiomyocyte "desmosomal reserve" which, if impaired genetically (e.g., PKP2 loss), accelerates progression of cardiomyopathy.

Keyphrases

high intensity
heart failure
physical activity
poor prognosis
resistance training
angiotensin ii
binding protein
high glucose