Naoxintong/PPARγ Signaling Inhibits Cardiac Hypertrophy via Activation of Autophagy.
Shuping YuanJianhua JinLu ChenYongzhong HouHong WangPublished in: Evidence-based complementary and alternative medicine : eCAM (2017)
As a traditional Chinese medicine, Naoxintong capsule (NXT) has been approved by China Food and Drug Administration (CFDA), which is used for cardiocerebrovascular disease treatment. Here we found that NXT extract significantly promoted H9c2 cardiomyocyte cell autophagy involved in increased autophagy-associated gene expression leading to inhibition of mTOR signaling. Moreover, NXT extract increased PPARγ protein expression and transcription activity of H9c2 cell. Consistent with this, in PPARγ gene silenced H9c2 cells, NXT had no effect on autophagy and mTOR signaling. Furthermore, NXT/PPARγ-mediated H9c2 autophagy led to inhibition of cardiomyocyte cell hypertrophy. These findings suggest that the extract of NXT inhibited H9c2 cardiomyocyte cell hypertrophy via PPARγ-mediated cell autophagy.
Keyphrases
- oxidative stress
- cell death
- single cell
- endoplasmic reticulum stress
- signaling pathway
- cell therapy
- induced apoptosis
- insulin resistance
- cell proliferation
- stem cells
- angiotensin ii
- cell cycle arrest
- adipose tissue
- fatty acid
- genome wide
- risk assessment
- climate change
- pi k akt
- anti inflammatory
- human health
- genome wide analysis