Involvement of APRIL in Helicobacter pylori-related gastric cancer.
Qun ZhangYing NiXiaofei ZhiJiwei WangZheng LiJie TangLinjun WangWeizhi WangZekuan XuPublished in: Journal of cancer research and clinical oncology (2021)
The expression of APRIL, which promoted the proliferation, migration, invasion, viability, and metastasis of GC cells, was upregulated in human H. pylori-infected GC through miR-145. Besides, APRIL-induced gastric tumorigenicity via activating NF-κB pathway. These results may provide a framework for the deeper analysis of APRIL in GC risk and prognosis.
Keyphrases
- helicobacter pylori
- signaling pathway
- induced apoptosis
- helicobacter pylori infection
- endothelial cells
- gas chromatography
- cell proliferation
- poor prognosis
- long non coding rna
- high glucose
- pi k akt
- cell cycle arrest
- oxidative stress
- diabetic rats
- cell death
- immune response
- inflammatory response
- tandem mass spectrometry