The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning.

Christa Ellen Nath Sebastian P A Rosser Kiran K NathJason ChungStephen LarsenJohn GibsonMelissa GabrielPeter J ShawSteven J Keogh

Published in: European journal of clinical pharmacology (2024)

Patient age and GFR are predictors of unbound F-Ara-A CLu. This has the potential to impact dose requirements. Dose individualisation by target concentration intervention will be facilitated by this model once it is externally validated.

Keyphrases

stem cell transplantation
high dose
patients undergoing
randomized controlled trial
emergency department
intensive care unit
binding protein
case report
low dose
small molecule
young adults
childhood cancer